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In addition, participants were excluded if were currently using a nicotine patch, had active substance abuse, are currently using tobacco products, were pregnant or lactating, had a history of diabetes, HIV infection, or were currently prescribed immunosuppressant medications or antibiotics or if another household member was enrolled in the study

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The freebase nicotine in earlier e-cigarettes was more easily absorbed in a users mouth and throat, a much slower path to the brain, nicotine researchers have found

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